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Seasonal Influenza - #MEDSHED

Updated: Jan 15

Welcome to the #MEDSHED! Needing a brief, concise review of clinical pharmacotherapy and disease management? Direct links of reference to content discussed? Look no further than the #MEDSHED series based on infographics and carousel presentations!
 


 

🤢 Influenza Virus: Antivirals - #MEDSHED



👋 Acute respiratory infection


Negative-strand RNA of Orthomyxoviridae family


Three types of influenza


Influenza A - Humans, swines, equines, birds, Higher susceptibility to antigen variant; pandemics


Influenza B


Influenza C



🤧 Signs and Symptoms


Cough


Fever


Myalgias


Chills/sweats


Malaise



💉 Prevention


CDC and AAFP recommend annual influenza vaccine (> 6 months). Emphasis on high-risk, immunocompromised, and healthcare professionals.



💊 Treatment (outpatient)


Primarily supportive care


Antivirals may be considered depending on severity and onset of symptoms


Antiviral agents only reduce severity of symptoms when taken < 48 hours of onset



🤖 Treatment (inpatient)


Hospitalized and those at high-risk of influenza-associated complications


CDC and IDSA recommend antiviral therapy regardless of symptom duration


Antivirals only reduce severity of symptoms



💊 Tamiflu (oseltamivir) - enteral


Neuraminidase inhibitor, decreases release of viral particles


Treatment: 75 mg po BID x 5 days, may consider longer in high risk


Px: 75 mg po daily (areas of outbreak)


Renally metabolized



Rapivab (peramivir) - IV


Neuraminidase inhibitor, decreases release of viral particles


Treatment (hospitalized): 600 mg IV daily x 5 - 10 days


Reserved for patients unable to tolerate enteral oseltamivir


Renally metabolized



🎥 For more #PHARMFAX in the drug bank, share the #MEDSHED with a friend, check out another post on my page, and I hope you learned something new.





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Not medical advice. Educational purposes only. No relationships to report.



References


Gaitonde DY, Moore FC, & Morgan MK. Am Fam Physician. 2019 Dec 15;100(12):751-758.


Uyeki TM, Bernstein HH, Bradley JS, et al. Clin Infect Dis. 2019 Mar 5;68(6):e1-e47.



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