๐ Clinical Statins: ACS/AIS - #MEDSHED
Statins are a mainstay of therapy for stroke and heart attack secondary prevention. They work by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, stimulating LDL catabolism. Additionally, statins contain pleoitropic properties, such as improved endothelial function, reduced inflammation, inhibit platelet aggregation, and anticoagulant effects
Monitoring - Side Effects
Hepatotoxicity Increased serum transaminases (ALT > AST)
Most cases occur within 3 months/dose increase
Muscle-related Myalgia, myopathy, rhabdomyolysis
Highest risk within first year of use, dose increase, or interacting medications
Guideline LDL-C Targets Acute Coronary Syndrome (ACS) - secondary prevention
Target: 50% reduction AND < 50 mg/dL
Acute Ischemic Stroke (AIS) - secondary prevention
Target: < 70 mg/dL
Unknown benefit when LDL-C levels are already low at time of stroke
High-intensity rosuvastatin has been associated with more effectiveness in reducing LDL vs atorvastatin
Let me know what thoughts and questions you have in the comments!
Website: www.pharmwyze.com
Shop: www.pharmwyze.com/shop
Social Links: https://links.pharmwyze.com
DrugQueryInbox Request: https://pharmwyze.hopp.to/drugqueryinbox
Streaming Platforms: https://pharmwyze.hopp.to/podstreams
Patreon: https://patreon.com/PHARMWYZE
Paypal Donation: https://pharmwyze.hopp.to/paypaldonate
PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsl...
Not medical advice. Educational purposes only. No relationships to report. #medicalschoolย #clinicalpearlsย #nursingschoolย #pharmacyschoolย #medicaleducationย #pharmacistย #pharmwyzeย #pharmfaxย #criticalcareย #emergencymedicineย #studentpharmacistย #nursingstudentย #medicalstudentย #pharmacyย #medicineย #nursingย #mededย #shortsย #rxshortsย #medigramย #medshedย #foamedย #emrxย #pharmacologyย #pharmacokineticsย #cardiologyย #antibioticsย #neurologyย #acs
Comments