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Continuous vs Intermittent Pantoprazole - #PHARMFAX

Stop taking up a line by running a pantoprazole drip through it.

 

Stop taking up a line by running a pantoprazole drip through it. Proton pump inhibitors inhibit gastric secretion and promote a hemostatic pH. For upper gastrointestinal bleeds, we’ve been basing the pantoprazole 80 mg IV bolus, then 8 mg/hr continuous infusion on recommendations from

2012.


Comparative and meta analysis associate intermittent pantoprazole 80 mg IV then 40 mg IV q 12 hrs with a similar incidence as rebleeding, blood transfusions, length of stay, and mortality compared to continuous pantoprazole.


Not many drugs are compatible with pantoprazole and you’re taking access away for blood, if needed.


The 80 mg load is important to achieve the target pH, incorporate that amongst the other boluses you’ll give, such as octreotide and ceftriaxone.


For more PHARMFAX in the drug bank, share with a friend who just matched to a residency.



Visit my website www.pharmwyze.com

References can also be found there.


Not medical advice. Educational purposes only. No relationships to report. I hope you learned something new.

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