top of page

Mannitol vs Hypertonic Saline for ICP Management - #MEDSHED

Updated: Nov 14, 2023

Welcome to the #MEDSHED! Needing a brief, concise review of clinical pharmacotherapy and disease management? Direct links of reference to content discussed? Look no further than the #MEDSHED series based on infographics and carousel presentations!

 


 

👻 Mannital vs Hypertonic Saline for ICP Management - #MEDSHED



🥗 Elevated intracranial pressures can be from traumatic brain injuries and other neurologic abnormalities resulting in cerebral edema. Both mannitol and hypertonic saline effectively reduce intracranial pressure.



When compared to either, there has been no proven difference in improved clinical outcomes or mortality. However, current evidence leans towards hypertonic saline being associated with a more rapid and sustained control of ICP.



🌊 Mannitol


Mechanism: osmotic diuresis, reduces blood viscosity that transiently increases cerebral blood flow and subsequent reduction in cerebral blood volume



Mannitol 20% 0.5 - 2 gm infused at 0.5 g over 30 - 60 minutes



Monitoring: Volume depletion/dehydration, AKI, shock



👾 Hypertonic saline


Mechanism: increases osmolarity of blood, draws water from brain (decreases overall ICP)



Sodium chloride 3% 250 - 500 mL IV piggyback, 23.4% 30 mL slow IV push



Monitoring: Hypernatremia, extravasation/tissue necrosis



Peripheral administration has shown to be safe in critically ill patients, central line preferred



📋 I'd really appreciate the support sharing my page, checking on my prior content (you can scroll for DAYS), drop by my pharmwyze.com/shop, and keep tuning in.



Social Medias: linktr.ee/pharmwyze






References


Mishra et al. Indian J Pediatr. 2023 Sep;90(9):899-906.


Miyoshi et al. J Intensive Care. 2020 Aug 12;8:61.


"Mannitol." Lexicomp, Wolters Kluwer,


"Sodium chloride preparations." Lexicomp, Wolters Kluwer,

6 views0 comments

Comments

Rated 0 out of 5 stars.
No ratings yet

Add a rating
bottom of page