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Scorpion Antivenom- #PHARMFAX

Updated: Jul 24, 2023

Scorpion venom toxins inhibits inactivation of sodium channels, resulting in prolonged depolarization and autonomic excitation.

 


Scorpion envenomation toxins inhibits inactivation of sodium channels, resulting in prolonged depolarization and autonomic excitation. Alpha-toxins, the more common toxin, cause a surge of catecholamine release. Severe envenomations are more attributed to sympathetic overstimulation compared to the parasympathetic nervous system. Adrenergic and cholinergic excess, in addition to neuromuscular excitation contribute to life-threatening complications. I’ve listed the clinical presentation above. Symptoms can include loss of muscle control, abnormal eye movements, slurred speech, excessie salivation, and respiratory distress. The cascade progresses into pulmonary edema, myocardial depression, and cardiogenic shock. Treatments are based on clinical grade. Patients with only local effects in Class I do not require antivenom. Class II - V with progressive systemic signs of envenomation and require a higher level of care, including antivenom. Anascorp, a scorpion antivenom, binds to and neutralizes venom toxins and facilitates them for elimination. The initial dose is three vials over 10 minutes, followed by another vial as needed every 30 to 60 minutes. It has shown to be extremely effective in rapidly resolving symptoms and less hypersensitivity reactions compared to older products. Common symptoms include nausea/vomiting and pyrexia. Caution with hypersensitivity reactions, including to equine products, and delayed serum sickness. Hit the like and follow button for more, and I hope you learned something new. Recommended Read/Watch Canine Bites: https://www.instagram.com/p/CuV5f6Mgjcv/ Rabies Post-Exposure Prophylaxis: https://www.instagram.com/p/Cp0FaQwIO7l/ The ALL PHARMWYZE SOURCE (including references) | www.pharmwyze.com #scorpionenvenomation #anascorp #toxin #antidote #poison #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded

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