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Protamine and Unfractionated Heparin - #PHARMFAX

Who would’ve known the drug that reverses unfractionated heparin derives from salmon sperm.

 

Who would’ve known the drug that reverses unfractionated heparin derives from salmon sperm. By itself, protamine is a basic compound that acts as a weak anticoagulant. When administered in the presence of heparin, protamine will bind to the highly acidic structure, and form a non-active salt compound with no anticoagulant effects. Dosing is based on prior infusion rates. Be mindful that rapid IV push can cause severe hypotension and anaphylactoid-like reactions. Protamine is a true antidote for unfractionated heparin in the setting of life-threatening bleed, but has variable efficacy in reversing low molecular weight heparin. The PHARMFAX are running hot, check out the other video’s on my page. All PHARMWYZE SOURCE www.pharmwyze.com References can also be found on website #protamine #heparin #pharmacy #twitterx #emergencymedicine #criticalcare Not medical advice. Educational purposes only. No relationships to report. I hope you learned something new.

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