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Antibiotics: Methicillin-Resistant Staphylococcus Aureus (MRSA) - #MEDSHED

Updated: Apr 30

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🐲🐲 Antibiotics: Methicillin-Resistant Staphylococcus Aureus (MRSA) - #MEDSHED



🚨 MRSA in the blood stream is an independent predictor of mortality. Methicillin-resistant staphylcoccus aureus (MRSA) has a become a common pathogen in the community, and known as a nosocomial organism looking for high risk patients.



🚨 Oral options are available IV and their difference in drug classes provides alternatives for true allergies. These include sulfamethoxazole-trimethoprim, doxycycline, linezolid, and clindamycin. Oral vancomycin is indicated only for Clostridium difficile.



🚨 Keep in mind safety pearls. Bactrim can cause AKI and hyperkalemia.


🚨 Doxycycline gets you sunburnt, but at least its not renally metabolized.


🚨 Linezolid develops thrombocytopenia with prolonged use.


🚨 Clindamycin has limited uses with high resistance and association with C. diff.



🚨It amazes me how vancomycin remains an effective first-line agent for MRSA. Vancomycin flushing syndrome is the new term, but nephrotoxicity isn’t.


🚨 Daptomycin provides once daily dosing. It does cause rhabdomylosis and is inactivated by lung surfactant.


🚨 Ceftaroline is the only beta-lactam indicated for MRSA. Its a newer generation than cefepime, but lacks pseudomonas coverage.


🚨 Ortivancin and dalbavancin are fairly recent, and provide one time dosing for skin infections.



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Not medical advice. Educational purposes only. No relationships to report.



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