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Heart Failure Guideline-Directed Medical Therapy (GDMT) - #MEDSHED

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Heart failure reduced ejection fraction (HFrEF) Guideline-Directed Medical Therapy

 

👿 Heart Failure Guideline-Directed Medical Therapy (GDMT) - #MEDSHED



🔥 GDMT has proven to reduce mortality and morbidity in patients with HFrEF (EF < 40%)


Drug classes include RAAS-I/ARNI, BB, MRA, and SGLT2-I



🔮 RAAS-I / ANRI


Entresto (sacubitril-valsartan) has shown to reduce all-cause death by 16% vs ACE-i


May consider RAAS-I (lisinopril, losartan, etc), switch to ARNI when clinically stable



📭 Beta Blockers


Beta blockers have been associated with a reduction in all-cause mortality by ~35%


Specific BB: bisoprolol, carvedilol, and metoprolol succinate



🌐 MRA


Spirinolactone may reduce the incidence of cardiovascular death and heart-failure associated hospitalization


Initiate after RAAS-I/ARNI and BB



👀 SGLT2-I


Dapagliflozin and empagliflozin have shown to reduce all-cause death by 13% and hospitalizations by 25% in HFrEF with or without T2DM


Caution with volume status of patients on diuretics



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Not medical advice. Educational purposes only. No relationships to report.



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