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Ketamine for Acute Agitation - #PHARMFAX

Ketamine’s ability to maintain hemodynamics, and routes of administration make it a versatile medication.

 

Ketamine’s ability to maintain hemodynamics, and routes of administration make it a versatile medication. Preferably, theres a step-wise approach to agitatead patients, but theres times where they’re at risk of harming themselves or the team.


Ketamine dissociates the brain from external stimuli through NMDA receptor antagonism. It should be reserved for severely agitated and/or combative patients. Ketamine dosed at 1 mg/kg IV and 3 - 4 mg/kg when given IM. Compared to antidopamanergic and benzodiazepines, ketamine provides a shorter median time to sedation within 5 to 15 minutes with more rapid onset with IV. The benefit does come with the risk of increased side effects.


Keep ketamine-induced apnea/laryngospasm, in addition to emergence reaction on your radar. Tachycardia and hypertension should be expected. Lastly, be mindful of interacting and additive sedative medications. For more #PHARMFAX in the drug bank, I’d appreciate hitting the like button, share the #PHARMFAX with a friend, and I hope you learned something new.


Recommended Read/Watch


Ketamine-induced Laryngospasm - https://www.instagram.com/p/Ctea4wZpNDQ/


Ketamie vs Etomidate in Unstable Patients - https://www.instagram.com/p/Cs5Q2JWghNY/


Pain Dose Ketamine - https://www.instagram.com/p/CqUfMVUgstX/


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